about lymphatic system disorders?please identify the causative factors for the following lymphatic system disorders,
hodgkin's disease, non=hodgkin's lymphoma, and multiple myeloma
thank you
Posted by Simon G
NHL- 1) Chromosomal translocations, 2) Inactivation of tumor suppressor genes, 3) Oncogenic virus (EBV, HTLV-I, HHV-B), 4) Aberrant somatic hypermutation
MM- 1) immunoglobulin gene rearangement 2) genetic changes 3) Cell cycle dysregulation 4) Dysregulation of apoptosis 5) Infection with HHV-8
HL- No known cause, but everything I've told you before this can apply. If your instructor tries to pawn off the fact that Epstein-Barr is associated with it, tell him/her that up to 85% of the population is infected with EBV and there aren't a large population with HL.
This is all I can remember from medical school, sorry
Sincerely,
Doc
Orignal From: about lymphatic system disorders?
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